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. 2017 Nov 28;57(16):4143–4148. doi: 10.1002/anie.201708408

Figure 1.

Figure 1

A B. subtilis globin variant, engineered by directed evolution, catalyzes the cyclopropanation of 3,4‐difluorostyrene to make the desired stereoisomer of a ticagrelor precursor with high selectivity and yield.7a