Table 5.
Linear Regression of Pharmacokinetic Parameter Estimates Versus eGFR or CLCR in Subjects After Oral Administration of 400 mg of Delafloxacin
| PK Parameter | Renal Function Measure | n | Slope Estimate | 95%CI of Slope Estimate | r 2 | P |
|---|---|---|---|---|---|---|
| AUC0–∞ (μg·h/mL) | eGFR | 30 | −0.189 | (−0.311 to ‐0.0661) | 0.262 | .0038 |
| CLCR | 30 | −0.168 | (−0.257 to ‐0.0800) | 0.353 | .0005 | |
| CLtot/F (L/h) | eGFR | 30 | 0.0985 | (0.0263–0.171) | 0.218 | .0093 |
| CLCR | 30 | 0.0918 | (0.0399–0.144) | 0.319 | .0011 | |
| CLr (L/h) | eGFR | 32 | 0.0654 | (0.0455–0.0852) | 0.601 | <.0001 |
| CLCR | 32 | 0.0511 | (0.0376–0.0647) | 0.664 | <.0001 | |
| Cmax (μg/mL) | eGFR | 32 | 0.0233 | (−0.00155 to 0.0482) | 0.109 | .0651 |
| CLCR | 32 | 0.00940 | (−0.00991 to 0.0287) | 0.032 | .328 |