FIGURE 1.

Distribution and density of TDP-43 morphological lesions; neuronal cytoplasmic inclusions (NCIs) (A), dystrophic neurites (DNs) (B), perivascular astrocytic inclusions (PVIs) (C), and oligodendroglial cytoplasmic inclusions (GCIs) (D). MC, motor cortex; Hp, hippocampal dentate fascia; EC, entorhinal cortex; Amg, amygdala; Put, putamen; GP, globus pallidus; Hyp, hypothalamus; nbM, nucleus basalis of Meynert; SN, substantia nigra; Mid T, midbrain tegmentum; LC, locus coeruleus; PT, pontine tegmentum; IO, Inferior olive nucleus; XII, hypoglossal nucleus; Med T, medullary tegmentum; SC, spinal cord anterior horn; TDP-43, TAR DNA-binding protein of 43 kDa.