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Effect on CSCs of LGR4 knockdown in human cancer cells
| Cells injected | 103 | 104 | 105 | 106 | CSC frequency |
|---|---|---|---|---|---|
| Control | 0/6 | 2/6 | 5/6 | 6/6 | 1/45,903 (18,996–110,925) |
| shLGR4 | 0/6 | 0/6 | 1/6 | 5/6 | 1/569,691 (235,901–1,375,781) |
Data shown as tumor outgrowths/mice injected with MDA-MB-231 cells. Calculated frequency of cancer stem cells and 95% confidence interval is denoted in the last column. P = 9.8e−05.
