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. 2018 Jan 8;32(5):2644–2657. doi: 10.1096/fj.201700722R

Figure 4.

Figure 4.

Epithelial TAZ up-regulation is associated with dedifferentiation and G2/M proliferative arrest. A) Similarly seeded CMV-Con– or CMV-TAZ–expressing HK-2 cells, maintained in complete medium for 5 d, were stained with crystal violet. Scale bars, 400 μm. B) Percentage of cells assuming a fibroblast morphology in CMV-Con– or CMV-TAZ–expressing HK-2 cultures. Means ± sd. *P < 0.05 vs. CMV-Con cells. C) The actual number of cells recovered from identically seeded (20,000 each) CMV-Con and CMV-TAZ cultures (n = 3) at d 3 and 5. *P < 0.05 at d 3 vs. CMV-Con cell count, **P < 0.001 at d 5 vs. CMV-Con cell count. D) Flow cytometry of propidium iodide–stained CMV-Con– and CMV-TAZ–expressing cells served to determine cell cycle distributions. E) The percentages of cells in the G1, S, and G2/M phases for each population for 3 separate studies. Data are expressed as means ± sd (B, C, E).