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. 2018 Jan 30;46(2):195–205. doi: 10.1002/bmb.21108

Figure 5.

Figure 5

dCas9 can bring different enzymatic activities to precise genomic locations. Through attaching different protein domains to dCas9, this modified version of the CRSISPR/Cas9 RNP can be used to repress gene expression (A), activate gene expression (B), add epigenetic modifiers (C), or tag DNA sequences with a fluorescent protein (D).