Table 4.
Pharmacokinetic Parameters of Ozanimod, RP101988, and RP101075
| Ozanimod | RP101988 | RP101075 | ||||
|---|---|---|---|---|---|---|
| Pharmacokinetic Parameter (Unit) | Day 10 (1 mg) | Day 14 (2 mg) | Day 10 (1 mg) | Day 14 (2 mg) | Day 10 (1 mg) | Day 14 (2 mg) |
| Cmax (pg/mL) | 205 (46.0) | 406 (74.3) | 354 (96.0) | 688 (186) | 63.7 (22.3) | 132 (49.5) |
| Cmin (pg/mL) | 81.0 (22.2) | 166 (40.7) | 98.0 (30.7) | 195 (53.1) | 17.3 (6.00) | 33.7 (10.9) |
| Tmax (h) | 6.08 (3.08‐12.08) | 6.08 (2.08‐12.08) | 6.08 (3.08‐8.12) | 4.08 (3.08‐8.08) | 6.08 (2.08‐12.08) | 6.08 (2.08‐8.12) |
| AUCτ (pg·h/mL) | 3405 (7667) | 6768 (1309) | 4930 (1358) | 9441 (2486) | 875 (290) | 1731 (525.6) |
| t1/2 (h) | NC | 20.1 (2.41) | NC | 19.1 (2.98) | NC | 21.5 (5.73) |
Data are presented as mean (SD) except for Tmax, which is expressed as median (range).
AUCτ indicates area under the plasma study drug concentration‐time curve during a dosage interval; Cmax, maximum observed plasma concentration; Cmin, minimum observed plasma concentration; NC, not calculated; Tmax, time to Cmax; t1/2, elimination half‐life.