Table 1.
PHQ-2 operating characteristics in medical samples.
| Population | Authors/year | PHQ-2 Cutoff score | PHQ-2 Operating characteristics | PHQ-9 Cutoff score | PHQ-9 Operating characteristics |
|---|---|---|---|---|---|
| Primary Care | Kroenke et al. (2003)17 | ≥3 | Sensitivity = 83%; Specificity = 90%; PPV = 38.4%; AUC = 0.93 | Not reported | AUC = 0.95 |
| Corson et al. (2004)19 | ≥3 | Sensitivity = 97%; Specificity = 91%; AUC = 0.94 | Not reported | Not reported | |
| Chen et al. (2009)20 | ≥3 | Sensitivity = 84%; Specificity = 90%; AUC = 0.92 | ≥9 | Sensitivity = 86%; Specificity = 85%; AUC = 0.92 | |
| Osorio et al. (2009)21 | ≥3 | Sensitivity = 97%; Specificity = 88%; PPV = 81%; NPV = 98%; AUC = 0.97 | ≥10 | Sensitivity = 100%; Specificity = 98%; PPV = 97%; NPV = 100%; AUC = 0.998 | |
| Arroll et al. (2009)22 | ≥2 | Sensitivity = 86%; Specificity = 78% | ≥10 | Sensitivity = 74%; Specificity = 91%; | |
| Phelan et al. (2010)23 | ≥2 | Sensitivity = 75%; Specificity = 67%; AUC = 0.81 | ≥9 | Sensitivity = 88%; Specificity = 80%; AUC = 0.87 | |
| Zuithoff et al. (2010)24 | ≥2 | Sensitivity = 81%; Specificity = 76%; PPV = 34%; NPV = 96%; AUC = 0.83 | ≥6 | Sensitivity = 82%; Specificity = 82%; PPV = 41%; NPV = 97%; AUC = 0.87 | |
| Liu et al. (2011)25 | ≥2 | Sensitivity = 88%; Specificity = 82%; AUC = 0.9 | ≥10 | Sensitivity = 86%; Specificity = 93.9%; AUC = 0.96 | |
| Inagaki et al. (2013)26 | ≥2 | Sensitivity = 77%; Specificity = 95%; PPV = 54%; NPV = 98%; AUC = 0.95 | ≥4 | Sensitivity = 86%; Specificity = 85%; PPV = 32%; NPV = 99%; AUC = 0.93 | |
| Thapar et al. (2014)27 | ≥3 | Sensitivity = 72.1%; Specificity = 82.1%; PPV = 53.5%; NPV = 91.2%; AUC = 0.87 | ≥11 | Sensitivity = 83.6%; Specificity = 83%; PPV = 58.4%; NPV = 94.7%; AUC = 0.9 | |
| Bhana et al. (2015)28 | ≥2 | Sensitivity = 60%; Specificity = 84%; AUC = 0.76 | ≥9 | Sensitivity = 49%; Specificity = 94%; AUC = 0.85 | |
| Carey et al. (2015)29 | ≥3 | Sensitivity = 91%; Specificity = 78%; PPV = 41%; NPV = 98%; AUC = 0.92 | ≥10 | Not reported | |
| Hanlon et al. (2015)30 | ≥1 | Sensitivity = 83.3%; Specificity = 60.8%; PPV = 11.7%; NPV = 98.3%; AUC = 0.78 | ≥5 | Sensitivity = 83.3%; Specificity = 74.7%; PPV = 17.1%; NPV = 98.6%; AUC = 0.85 | |
| Suzuki et al. (2015)31 | ≥3 | Sensitivity = 76%; Specificity = 82%; Overall Accuracy = 81%; PPV = 27%; NPV = 98%; AUC =.845 | ≥11 | Sensitivity = 76%; Specificity = 81%; Overall Accuracy = 81%; PPV = 26%; NPV = 97%; AUC = 0.88 | |
| Stroke | de Man-van Ginkel, Gooskens, et al. (2012)32 | ≥2 | Sensitivity = 100%; Specificity = 77%; PPV = 38%; NPV = 100% | ≥10 | Sensitivity = 100%; Specificity = 86%; PPV = 50%; NPV = 100% |
| de Man-van Ginkel, Hafsteinsdottir, et al. (2012)33 | ≥2 | Sensitivity = 75%; Specificity = 76%; AUC = 0.82 | ≥10 | Sensitivity = 80%; Specificity = 78%; AUC = 0.87 | |
| Turner et al. (2012)34 | ≥1 | Sensitivity = 77%; Specificity = 63%; AUC = 0.82 | ≥6 | Sensitivity = 85%; Specificity = 63%; AUC = 0.82 | |
| Cardiovascular | McManus et al. (2005)35 | ≥3 | Sensitivity = 39%; Specificity = 92%; AUC = 0.84 | ≥10 | Sensitivity = 54%; Specificity = 90%; AUC = 0.86 |
| Thombs et al. (2008)36 | ≥2 | Sensitivity = 82%; Specificity = 79%; PPV = 52%; NPV = 94%; AUC = 0.84 | ≥6 | Sensitivity = 83%; Specificity = 76%; PPV = 50%; NPV = 94%; AUC = 0.86 | |
| Wang et al. (2015)37 | ≥3 | Sensitivity = 85.7%; Specificity = 69.2%; PPV = 57.1%; NPV = 93.6%; AUC = 0.806 | ≥10 | Sensitivity = 87.1%; Specificity = 83.5%; PPV = 58.7%; NPV = 95.6%; AUC = 0.877 | |
| HIV/AIDS | Monahan et al. (2008)38 | ≥3 | Sensitivity = 91%; Specificity = 77%; PPV = 36.9; AUC = 0.91 | Not reported | Not reported |
| Cognitive Impairment | Boyle et al. (2011)39 | ≥3 | Sensitivity = 78%; Specificity = 71%; AUC = 0.81 | ≥10 | Sensitivity = 89%; Specificity = 71%; AUC = 0.85 |
| Epilepsy | Fiest et al. (2014)40 | ≥2 | Sensitivity = 42.3%; Specificity = 87.3%; PPV = 35.5%; NPV = 90.1%; AUC = 0.75 | ≥9 | Sensitivity = 82.6%; Specificity = 82.2%; PPV = 42.2%; NPC = 96.8%; AUC = 0.88 |
| Migraine | Seo et al. (2015)41 | ≥2 | Sensitivity = 66.7%; Specificity = 90.3%; PPV = 74.3%; NPV = 86.6%; AUC = 0.785 | ≥7 | Sensitivity = 79.5%; Specificity = 81.7%; PPV = 64.6%; NPV = 90.5%; AUC = 0.806 |
| Multiple Sclerosis | Amtmann et al. (2015)42 | ≥2 | Sensitivity = 70.8%; Specificity = 81% | ≥10 | Sensitivity = 93.8%; Specificity = 61.2% |
| Patten et al. (2015)43 | ≥3 | Sensitivity = 80%; Specificity = 93%; PPV = 64%; NPV = 36%; AUC = 0.943 | ≥11 | Sensitivity = 95%; Specificity = 88.3%; PPV = 55.9%; NPV = 44.1%; AUC = 0.952 |