. 2018 Feb 19;41(1):154–166. doi: 10.1590/1678-4685-GMB-2017-0091

Table 4. Reference values and results related to the differential blood cell count.

Experimental Groups	Cell types
	55-95%	10-40%	0.0-0.3%	0.0-0.4%	0.1-3.5%
	Lymphocytes²	Neutrophils²	Basophils¹	Eosinophils¹	Monocytes²
LOT 1
NC	67 ± 0.74	22.0 ± 0.81	0 ± 0.001	0 ± 0.00	10.0 ± 0.40
IR-01 12 mg/kg	78 ± 1.48^a*	11.0 ± 0.67^a*	0 ± 0.00^a	0 ± 0.00^a	9.6 ± 0.50^a*
IR-01 24 mg/kg	82 ± 1.00^a*	8.0 ± 0.63ª^*	0 ± 0.00^a	0 ± 0.00^a	6.8 ± 1.31^a*
IR-01 48 mg/kg	86 ± 0.81^a*	9.0 ± 0.87^a*	0 ± 0.00^a	0 ± 0.00^a	4.6 ± 1.74^a*
LOT 2
DOX	76 ± 2.46ª^*	12 ± 0.67ª*	0 ± 0.00^a	2.81.31^a	9.4 ± 1.83^a*
+IR-01 12 mg/kg	85 ± 1.53^b*	8.4 ± 1.03^b*	0 ± 0.00^b	1.80.58^b	3.6 ± 0.92^b*
+IR-01 24 mg/kg	85 ± 1.68^b*	11.00.58^b	0 ± 0.00 ^b	1.4 ± 0.92^b	1.4 ± 0.50^b*
+IR-01 48 mg/kg	891.58^b*	7.0 ± 0.47^b*	0 ± 0.00^b	2.5 ± 1.50^b	1.2 ± 0.62^b*
LOT 3
CIS	78 ± 0.73ª^*	17 ± 1.88^a	0 ± 0.00^a	0 ± 0.00^a	3.4 ± 1.32^a*
+IR-01 12 mg/kg	83 ± 2.62^c	10 ± 1.20^c*	0 ± 0.00^c	0.2 ± 0.20^c	6.4 ± 0.00^c
+IR-01 24 mg/kg	85 ± 1.36^c*	10 ± 0.96^c*	0 ± 0.00^c	0 ± 0.00^c	4.2 ± 0.76^c
+IR-01 48 mg/kg	85 ± 1.00^c*	10 ± 0.50^c*	0 ± 0.00^c	0 ± 0.00^c	4.4 ± 0.67^c
LOT 4
CPP	85 ± 3.49ª^*	11 ± 3.53^a	0 ± 0.00ª	0 ± 0.00^a	2.81.06^a*
+IR-01 12 mg/kg	85 ± 3.92^d	10 ± 2.64^d	0 ± 0.00^d	0 ± 0.00^d	4.2 ± 1.35^d
+IR-01 24 mg/kg	92 ± 2.31^d	4.6 ± 1.60^d	0 ± 0.00^d	0 ± 0.00^d	3.0 ± 1.00^d
+IR-01 48 mg/kg	86 ± 0.48^d	11 ± 0.50^d	0 ± 0.00^d	0 ± 0.00^d	1.8 ± 0.86^d

Data is represented as mean values ± standard error of the mean. Statistical tests: ⁽¹⁾Student’s t-test(p < 0.05) and ⁽²⁾Mann-Whitney test (p < 0.05). NC: Negative control group; ^(a)Statistically compared to the NC group; ^(b)Statistically compared to the DOX group; ^(c)Statistically compared to the CIS group; ^(d)Statistically compared to the CPP group; ^*statistically different.