Table II.

All Grade ≥3 Adverse Events

	Adverse Events by Grade, n (%)
	FND→R N = 78		RFND N = 80
Toxicity*	3	4	3	4
Non-haematological
Anxiety/depression	5 (6)	1 (1)	2 (3)	1(1)
Fatigue	13 (17)	2 (3)	10 (13)	2 (3)
Neutropenic fever	16 (21)	0	13 (16)	0
Infection	6 (8)	2 (3)	13 (16)	0
Nausea/emesis	3 (4)	1 (1)	4 (5)	0
Haematological
Neutropenia	13 (17)	54 (69)	13 (16)	64 (80)
Thrombocytopenia	10 (13)	5 (6)	14 (18)	9 (11)
Anaemia	3 (4)	7 (9)	5 (6)	6 (8)

FND→R, sequential fludarabine, mitoxantrone, dexamethasone followed by rituximab; RFND, concurrent fludarabine, mitoxantrone, dexamethasone and rituximab