Skip to main content
. Author manuscript; available in PMC: 2018 Dec 18.
Published in final edited form as: Dev Cell. 2017 Dec 7;43(6):689–703.e5. doi: 10.1016/j.devcel.2017.11.008

Figure 6. dATM plays a key role in the dDP depleted fatbody cells.

Figure 6

A: Genetic screen performed in the fatbody. Parallel crosses of cgRFP-UAS dDPRNAi were set with UAS LucRNAi and UAS (X)RNAi candidate lines. B: List of dE2F regulated candidates (columns indicate direct ChIP binding of E2F1 (E1), E2F2 (E2) and RBF (RB)) and screen result (rescue of nuclear shape defects). C: Representative fatbody nuclei from cgRFP>+ (control), cgRFP-UAS dDPRNAi>UAS LucRNAi (defective), and cgRFP-UAS dDPRNAi>UAS ATMRNAi (TRIP) (rescued). D: % animals arrested at each developmental stage in cgRFP>+, cgRFP-UAS dDPRNAi>UAS LucRNAi (n=190) and UAS ATMRNAi (TRIP) animals (n=100, Chi-square test, p-val<0.0001). E: Induced DNA replication in cgRFP>dATM fatbodies (arrowheads: whole replicating nuclei. EdU, green; control, cgRFP>+).