Table 1.

	All Cohorts (n=1036)	Cohort A (n=469)	Cohort B (n=335)	Cohort C (n=232)	p- value
Demographics
Age (years)	57 [45-67]	49 [34-64]	59 [49-68]	63 [57-71]	<0.001
Body Mass Index (kg/m2)	27.7 [23.9-33.3]	26.2 [19.1-33.4]	28.4 [25.0-33.0]	31.8 [26.0-38.4]	<0.001
Female Gender	400 (39)	167 (36)	89 (27)	144 (61)	<0.001*
Race
Black	256 (37)	169 (36)		87 (38)
Caucasian	411 (59)	289(62)	NA	122 (52)
Other	32 (4)	9(2)		23 (10)	<0.001*
Diagnosis
Non-Ischemic	557 (80)	423 (90)	NA	134 (58)
Ischemic	144 (20)	46 (10)	NA	98 (42)	<0.001*
Hemodynamics
Heart rate (beats per minute)	81 [69-97]	92 [75-111]	75 [66-87]	71 [63-80]	<0.001
Systemic Blood Pressure
Systolic (mmHg)	121 [106-139]	118 [91-145]	NA	124 [112-138]	0.097 †
Diastolic (mmHg)	75 [66-84]	78 [62-94]	NA	70 [60-77]	<0.001 †
Mean (mmHg)	90 [81-102]	91 [73-109]	NA	87 [81-97]	<0.001 †
Systemic Vascular Resistance (WU)	18 [13-25]	21 [12-30]	NA	12.3 [9.4-15.5]	<0.001 †
Left Ventricular Stroke Work Index (mmHg ml/m2)	1685 [1154-2510]	1375 [654-2096]	NA	2595 [1886-3168]	<0.001 †
Right Atrial Pressure (mmHg)	13 [9-18]	11 [5-17]	14.7 [10-19]	15 [12-20]	<0.001
Pulmonary Artery Pressures
Systolic (mmHg)	53 [45-63]	52 [40-64]	54 [46-64]	53 [45-66]	0.038
Diastolic (mmHg)	27 [22-31]	27 [21-33]	26 [22-31]	27 [23-33]	0.051
Mean (mmHg)	35 [30-42]	35 [27-43]	36 [30-42]	36 [30-43]	0.130
Pulmonary Artery Wedge Pressure (mmHg)	25 [20-35]	25 [19-31]	24 [20-28]	25 [21-31]	0.006
Cardiac Index (L/min/m2)	2.2 [1.7-2.7]	1.9 [1.3-2.5]	2.0 [1.7-2.4]	2.9 [2.4-3.4]	<0.001
Right Ventricular Stroke Work Index (mmHg ml/m2)	598 [407-835]	517 [275-761]	629 [410-846]	866 [612-1200]	<0.001
Pulmonary Effective Arterial Elastance (mmHg/ml)	1.0 [0.7-1.5]	1.3 [0.6-2.0]	1.0 [0.8-1.4]	0.6 [0.5-0.9]	<0.001
Pulmonary Artery Compliance (ml/mmHg)	2.0 [1.4- 2.9]	1.6 [0.7-2.6]	1.9 [1.4-2.5]	3.2 [2.4-4.7]	<0.001
Pulmonary Vascular Resistance (WU)	2.3 [1.4-3.5]	2.4 [0.5-4.3]	2.8 [1.8-4.1]	1.7 [1.1-2.5]	<0.001
Transpulmonary Gradient (mmHg)	11 [7-14]	9 [3.5-14 .5]	11 [7.0-15.3]	10 [8.0-14.0]	<0.001
Diastolic Pulmonary Gradient (mmHg)	1 [-1.0 – 5.0]	1 [-3.9 - 5.9]	1.3 [-1.0 - 5.0]	0 [0 – 3.0]	0.078
RA/PCWP	0.5 [0.3-0.7]	0.4 [0.2-0.6]	0.5 [0.4-0.70]	0.6 [0.4-0.7]	<0.001

Data presented as median [interquartile range]

ANOVA or Kruskal Wallis test unless otherwise indicated

^*Chi-square,

^†Rank Sum test

() = Percentage