Table 2.

	All Cohorts			Cohort A			Cohort B			Cohort C
	Hazard Ratio (95% CI) per unit increase	P-value	x²	Hazard Ratio (95% CI) per unit increase	P-value	x²	Hazard Ratio (95% CI) per unit increase	P-value	x²	Hazard Ratio (95% CI) per unit increase	P-value	x²
Ea
Unadjusted	1.41 (1.26-1.59)	<0.001	34.0	1.26 (1.06-1.51)	0.009	6.9	1.65 (1.23-2.22)	0.001	10.9	1.60 (1.13-2.27)	0.008	7.0
Adjusted^*	1.47 (1.31-1.65)	<0.001	44.3	1.25 (1.08-1.49)	0.012	6.3	1.64 (1.22-2.20)	0.001	10.9	1.44 (0.99-2.10)	0.053	7.8
Adjusted^†	1.45 (1.27-1.65)	<0.001	29.6	1.30 (1.08-1.56)	0.005	7.8	1.72 (1.23-2.42)	0.002	9.8	1.47 (0.97-2.23)	0.069	3.3
PAC^‡
Unadjusted	1.30 (1.19-1.41)	<0.001	35.8	1.22 (1.03-1.45)	0.021	5.3	1.45 (1.18-1.82)	0.001	11.3	1.22 (1.06-1.41)	0.006	7.7
Adjusted^*	1.33 (1.22-1.45)	<0.001	41.0	1.19 (1.02-1.41)	0.033	4.5	1.37 (1.11-1.72)	0.004	8.3	1.16 (1.01-1.35)	0.042	4.1
Adjusted^†	1.30 (1.18-1.43)	<0.001	29.3	1.26 (1.04-1.52)	0.017	5.6	1.37 (1.09-1.73)	0.007	7.2	1.15 (0.99-1.34)	0.076	3.2
PVR
Unadjusted	1.16 (1.11-1.21)	<0.001	40.2	1.13 (1.06-1.20)	<0.001	12.9	1.12 (1.04-1.21)	0.002	9.3	1.18 (1.01-1.37)	0.035	4.4
Adjusted^*	1.15 (1.10-1.20)	<0.001	36.5	1.10 (1.03-1.18)	0.004	8.4	1.11 (1.03-1.20)	0.007	7.3	1.11 (0.94-1.30)	0.22	1.5
Adjusted^†	1.14(1.08-1.19)	<0.001	27.8	1.11 (1.04-1.19)	0.003	8.8	1.12 (1.03-1.21)	0.005	7.8	1.08 (0.92-1.28)	0.36	0.8
TPG
Unadjusted	1.02 (1.00-1.04)	0.003	8.8	1.02 (1.00-1.05)	0.025	5.0	1.01 (0.99-1.04)	0.15	2.1	1.03 (0.99-1.06)	0.17	1.9
Adjusted^*	1.02 (1.00-1.03)	0.011	6.5	1.02 (1.00-1.05)	0.071	3.2	1.02 (0.99-1.04)	0.12	2.4	1.02 (0.98-1.06)	0.27	1.2
Adjusted^†	1.02 (1.01-1.04)	0.004	8.2	1.03 (1.00-1.05)	0.042	4.1	1.02 (1.00-1.05)	0.063	3.4	1.02 (0.98-1.06)	0.27	1.2
DPG
Unadjusted	1.01 (0.99-1.03)	0.30	1.0	1.02 (1.00-1.05)	0.095	2.6	1.00 (0.97-1.03)	0.90	0.1	0.98 (0.90-1.06)	0.55	0.3
Adjusted^*	1.01 (0.99-1.03)	0.29	1.0	1.02 (0.99-1.05)	0.12	2.2	1.01 (0.98-1.04)	0.44	0.6	0.98 (0.90-1.06)	0.66	0.2
Adjusted^†	1.01 (0.99-1.03)	0.17	1.9	1.02 (1.00-1.05)	0.099	2.7	1.01 (0.99-1.04)	0.36	0.8	0.99 (0.91-1.07)	0.78	0.1

The outcome is all-cause mortality.

Adjusted model accounts for age.

^†

Adjusted model accounts for age, gender, body mass index, heart rate, and cohort.

^‡

HRs are per one-unit decrease in PAC. Ea = Pulmonary effective elastance. PAC = Pulmonary artery compliance, PVR = Pulmonary vascular resistance. TPG = Transpulmonary gradient. DPG = Diastolic pulmonary gradient.