Skip to main content
. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Mol Immunol. 2018 Apr 4;97:101–108. doi: 10.1016/j.molimm.2018.03.031

Fig. 1.

Fig. 1

Somatic hypermutation in the IgH locus of Ramos cells. A) Wild type, and B) Δ intron. Arrow marks the transcription start site. Green boxes represent L and VDJ exons; yellow oval depicts the area targeted for SHM (Qian et al., 2014); white ovals signify the Eμ enhancer and Sμ region; and black box represents the Cμ1 exon. Pink dotted lines show the deletion. E, EcoRI. C) Nucleotide sequence (613 bp) that was deleted downstream of the EcoR1 site (underlined) is marked by red dashes. The rearranged JH6 gene segment is underlined for reference.