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. Author manuscript; available in PMC: 2019 Apr 11.
Published in final edited form as: Cell Host Microbe. 2018 Apr 11;23(4):536–548.e6. doi: 10.1016/j.chom.2018.03.009

Fig. 7. A model for HIV-1 uncoating and nuclear entry.

Fig. 7

Functional HIV-1 uncoating occurs through multiple steps involving early core opening and subsequent terminal loss of CA at the NE, prior to intra-nuclear transport to sites of integration. Terminal uncoating in the cytoplasm leads to proteasomal targeting of the IN complexes, while the failure to uncoat after docking at the NE results in block to nuclear import. The N74D/CA mutant that uses an alternative nuclear import pathway also uncoats at the NE, but fails to move away from the NE, leading to peripheral integration.