Table 2. Primary and secondary endpoints analysed using an ANCOVA model.
Data presented as absolute changes from baseline to 30 min.
| Saline | Paracetamol | ||||||
|---|---|---|---|---|---|---|---|
| Baseline | Absolute Change | Baseline | Absolute Change | Mean between-group difference in absolute change | 95% CI |
p value (adjusted between-group difference) |
|
| SBP* (mmHg) (Primary outcome) | 130 (24) | -1 (11) | 136 (21) | -13 (18) | -11 | -20 to -2 | 0.02 |
| DBP (mmHg) | 61 (10) | 0 (6) | 67 (11) | -8 (9) | -6 | -11 to -2 | 0.01 |
| MAP (mmHg) | 87 (17) | -1 (8) | 90 (12) | -9 (12) | -7 | -12 to -1 | 0.02 |
| sPAP (mmHg) | 31 (11) | 1 (7) | 27 (9) | 2 (7) | 1 | -3 to 5 | 0.65 |
| dPAP (mmHg) | 14 (7) | 1 (5) | 15 (6) | 1 (5) | 0 | -3 to 3 | 0.99 |
| mPAP (mmHg) | 23 (13) | -1 (5) | 19 (8) | 1 (5) | -0.3 | -3 to 3 | 0.83 |
| CVP (mmHg) | 7 (5) | 1 (3) | 9 (5) | -1 (5) | -1.5 | -4 to 1 | 0.16 |
| HR (beats min-1) | 66 (12) | -2 (7) | 72 (13) | -1 (6) | 2 | -1 to 6 | 0.21 |
| CI (L min-1 m2) | 2.49 (1.00) | 0 (1) | 2.72 (1.02) | 0 (1) | 0.1 | -0.2 to 0.5 | 0.41 |
| SVRI (dynes sec-1 cm-1 m2) | 2746 (680) | -166 (493) | 2695 (1027) | -332 (617) | -182 | -465 to 102 | 0.20 |
*ANCOVA model with the SBP value at 30 min as an outcome, the treatment group as a factor, and the baseline SBP value as a treatment covariate.