Fig. 3.

CMPD1 induced gastric cancer cell apoptosis by suppressing the expression of c-Myc and Bcl-2. a After treatment of MKN-45 cell line with indicated concentration of CMPD1 for 24 h, the expression of cleaved PARP, c-Myc, Bax, Bcl-2 and cytochrome c release were analyzed by western blot, GAPDH and β-actin were used as internal controls. b The ratio of cleaved PARP, c-Myc, Bax and Bcl-2 to GAPDH and cytosolic cytochrome c to β-actin was performed in densitometry analyzed by IMAGE J software. Data are expressed using Student’s test, *P < 0.05, **P < 0.01 and ***P < 0.001