Table 1.
Baseline characteristics of women age ≥ 65 by Medicare fee-for-service coverage (Part A/B) status at the time of entry into the Women’s Health Initiative hormone therapy clinical trials.
| CEE+MPA Trial | CEE-Alone Trial | |||||
|---|---|---|---|---|---|---|
| Has Part A/B (n=4557) |
Does not have Part A/B (n=2746) |
P value | Has Part A/B (n=3107) |
Does not have Part A/B (n=1836) |
P value | |
| Age at screening, y | 70.0±3.7 | 70.1±3.8 | 0.44 | 70.3±3.7 | 70.1±3.7 | 0.044 |
| Age stratum, y | ||||||
| 60-69 | 51.3 | 50.6 | 0.68 | 46.5 | 50.2 | 0.036 |
| 70-79 | 48.7 | 49.4 | 53.5 | 49.8 | ||
| Race | ||||||
| White | 92.0 | 85.4 | <0.0001 | 84.7 | 78.2 | 0.92 |
| Black | 4.2 | 4.9 | 10.7 | 12.6 | ||
| Hispanic | 1.5 | 4.4 | 2.1 | 4.7 | ||
| Asian | 1.3 | 3.6 | 1.1 | 2.2 | ||
| American Indian | 0.1 | 0.3 | 0.4 | 0.6 | ||
| Other | 0.9 | 1.4 | 1.0 | 1.7 | ||
| Years since menopause, y | ||||||
| <10 | 3.2 | 2.8 | 0.60 | 2.3 | 3.5 | 0.05 |
| 10-<20 | 47.5 | 47.0 | 22.1 | 22.7 | ||
| ≥ 20 | 49.3 | 50.2 | 75.6 | 73.8 | ||
| Hormone use | ||||||
| Never | 78.4 | 73.8 | <0.0001 | 54.5 | 50.1 | <0.0001 |
| Past | 19.3 | 20.8 | 38.6 | 38.1 | ||
| Current | 2.3 | 5.4 | 6.9 | 11.8 | ||
| Vasomotor symptoms | 60.7 | 60.1 | 0.59 | 61.9 | 59.9 | 0.18 |
| Body mass index (kg/m2) | 27.9±5.4 | 28.0±5.5 | 0.38 | 29.1±5.5 | 29.3±5.7 | 0.26 |
| Systolic blood pressure (mmHg) | 132.8±18.3 | 132.0±18.0 | 0.12 | 134.3±18.5 | 134.4±17.7 | 0.82 |
| Diastolic blood pressure (mmHg) | 75.2±9.5 | 74.7±9.3 | 0.02 | 75.4±9.6 | 75.3±9.8 | 0.73 |
| Smoking | ||||||
| Never | 52.9 | 52.4 | 0.71 | 55.6 | 53.1 | 0.23 |
| Past | 40.5 | 40.5 | 27.3 | 39.5 | ||
| Current | 6.6 | 7.1 | 7.1 | 7.4 | ||
| Never pregnant | 92.1 | 93.0 | 0.17 | 93.3 | 92.9 | 0.62 |
| Age at time of first birth, y | ||||||
| <20 | 11.9 | 11.7 | 0.99 | 18.6 | 20.0 | 0.06 |
| 20-29 | 75.4 | 75.3 | 74.0 | 72.8 | ||
| ≥ 30 | 12.7 | 13.0 | 7.4 | 7.2 | ||
| Bilateral oophorectomy | 0.3 | 0.4 | 0.71 | 43.9 | 44.2 | 0.85 |
| Medications at baseline | ||||||
| Diabetes class | 4.0 | 4.5 | 0.29 | 7.3 | 7.7 | 0.58 |
| Statin class | 9.0 | 10.6 | 0.033 | 10.8 | 11.1 | 0.79 |
| Salicylate class | 28.0 | 25.5 | 0.021 | 28.3 | 25.5 | 0.034 |
| Past Medical History | ||||||
| Hypertension ever | 34.9 | 35.8 | 0.38 | 44.4 | 45.5 | 0.45 |
| MI ever | 2.6 | 3.1 | 0.20 | 4.0 | 4.9 | 0.13 |
| Angina ever | 5.4 | 6.5 | 0.05 | 9.8 | 9.9 | 0.92 |
| CABG/PCI | 2.2 | 1.9 | 0.36 | 3.5 | 2.9 | 0.24 |
| Stroke | 1.0 | 1.7 | 0.016 | 2.0 | 2.2 | 0.53 |
| Venous thromboembolism | 0.9 | 1.1 | 0.33 | 1.6 | 1.3 | 0.35 |
| Fracture at age 55+ * | 24.7 | 23.8 | 0.46 | 23.9 | 22.5 | 0.29 |
| Family history of breast cancer** | 36.1 | 35.7 | 0.48 | 36.4 | 36.9 | 0.81 |
| Region | ||||||
| Northeast | 24.2 | 23.8 | 23.6 | 23.4 | 0.84 | |
| South | 21.3 | 21.0 | 0.91 | 24.1 | 23.1 | |
| Midwest | 24.3 | 25.0 | 24.3 | 24.9 | ||
| West | 30.2 | 30.2 | 28.0 | 28.6 | ||
| Family Income ≥ $50,000 | 21.6 | 20.7 | 0.34 | 16.2 | 15.1 | 0.32 |
| Education > high school degree or | 71.7 | 72.8 | 0.33 | 65.7 | 66.8 | 0.43 |
| GED | ||||||
*
Missing 15% data.
**
Missing 55% data.