Table 2.
The effect of thymoquinone on antioxidant enzymes in doxorubicin-mediated cardiotoxicity in the mice.
| Groups and treatments | CAT (nmole of H2O2 consumed/min/mg/protein) | SOD (nmol epinephrine protected from oxidation/min/mg protein) | GPx (nmol NADPH oxidized/min/mg/protein) | GR (nmol NADPH oxidized/min/mg protein) | GST (nmol CDNB conjugate/min/mg protein) |
|---|---|---|---|---|---|
| Group A (control) | 35.93 ± 2.4 | 12.51 ± 1.56 | 160.05 ± 3.10 | 415.89 ± 1.34 | 159.79 ± 4.56 |
| Group B (DOX) | 15.34 ± 2.60∗ | 5.29 ± 1.78∗∗∗ | 83.94 ± 3.72∗∗ | 217.38 ± 2.34∗∗ | 80.26 ± 4.21∗∗ |
| Group C (DOX + Q10) | 38.23 ± 2.30∗ | 8.45 ± 1.58∗∗ | 115.34 ± 2.14∗∗ | 384.13 ± 2.13∗ | 120.46 ± 3.54∗ |
| Group D (DOX + TQ-20) | 34.45 ± 2.11∗∗ | 10.34 ± 1.36∗∗∗ | 143.67 ± 2.13∗ | 420.22 ± 1.65∗∗∗ | 159.87 ± 2.45∗∗∗ |
| Group E TQ-20 | 30.23 ± 1.23∗∗ | 13.56 ± 2.10∗∗ | 167.45 ± 1.46∗ | 428.00 ± 1.34∗ | 156.08 ± 2.33∗∗ |
Each value is the mean of six replicates with standard deviation; ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001 were significant when compared to normal control (Group A) and toxic control (Group-B) by performing Tukey–Kramer test.