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. Author manuscript; available in PMC: 2018 Apr 16.
Published in final edited form as: Lab Invest. 2017 Jun 5;97(7):843–853. doi: 10.1038/labinvest.2017.29

Figure 2.

Figure 2

Suppression of Nf2 mutant intrahepatic bile duct development phenotypes by loss of Notch2 (P0). (a and b) H&E staining (a) and CK19 staining (b) of large portal vein area in P0 Control, Nf2, Nf2;Notch2+/− and Nf2;Notch2 livers. Arrows, primitive ducts. Arrowheads, nontubular ductal plate structures. Scale bars =50 μm. (c) Quantification of CK19-positive cholangiocytes for P0 livers. (d) Quantification of primitive ducts for P0 livers. (e) Comparison of body weights for P0 mice. Bars represent mean ±s.e.m. (n= 3 mice from each genotype). *P<0.05, compared with control, #P<0.05, compared with Nf2, one-way ANOVA and Fisher's LSD