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. Author manuscript; available in PMC: 2018 Apr 16.
Published in final edited form as: Lab Invest. 2017 Jun 5;97(7):843–853. doi: 10.1038/labinvest.2017.29

Figure 5.

Figure 5

Cholangiocyte proliferation continues in adult Nf2;Notch2+/− and Nf2;Notch2 mice. (a) Gross liver images from 8-week-old animals. Note the formation of biliary hamartoma in Nf2, Nf2;Notch2+/− and Nf2;Notch2 livers (indicated by arrows and confirmed by CK19 staining in b). Scale bar= 0.5 cm. (b) CK19 staining of the biliary hamartoma shown in a, Scale bar= 100 μm. (c) CK19 staining of deep parenchymal area of control, Nf2, Nf2; Notch2+/− and Nf2;Notch2 livers from 8-week-old animals. Scale bar = 100 μm. (d) Quantification of liver-to-body ratio of 8-week-old animals. Bars represent mean± s.e.m. (n = 3 mice from each genotype). *P<0.05, compared with wild-type control, one-way ANOVA and Fisher's LSD.