TABLE 1.
Baseline patient characteristics
| Characteristics | N (%) | ||
|---|---|---|---|
| Overall (N = 1245) | CNS− (N = 1194) | CNS1 (N = 51) | |
| Age > 64 years | 665 (53) | 645 (54) | 20 (39) |
| Prior HiDAC | 985 (79) | 945 (79) | 40 (78) |
| Refractory/Relapse | 582 (47)/663 (53) | 561(47)/633 (53) | 21 (41)/30 (59) |
| Poor cytogenetics | 394 (32) | 384 (32) | 10 (20) |
| FAB M4/M5 | 276 (22) | 259 (22) | 17 (33) |
| FLT3-ITD mutation | 160 (13) | 145 (12) | 15 (29) |
| FLT3-D835 mutation | 41 (3) | 40 (3) | 1 (2) |
| NPM1 mutation | 95 (8) | 92 (8) | 3 (6) |
| RAS mutation | 89 (7) | 83 (7) | 6 (12) |
| AHD | 494 (40) | 482 (40) | 12 (24) |
| WBC > 10 × 109/L | 432 (35) | 406 (34) | 26 (51) |
| LDH > 1000 IU/L | 448 (36) | 417 (35) | 31 (61) |
| Platelets > 49 × 109/L | 606 (49) | 582 (49) | 24 (47) |
| Hgb > 8.7 g/dL | 565 (51) | 543 (47) | 22 (44) |
| BM blasts > 50% | 518 (42) | 492 (41) | 26 (51) |
| PB Blasts > 50% | 279 (22) | 263 (22) | 16 (31) |
| Albumine > 3.5 g/dL | 535 (45) | 514 (45) | 21 (42) |
| Bilirubin > 0.5 mg/dL | 554 (44) | 527 (44) | 27 (53) |
| Creatinine > 0.9 mg/dL | 528 (42) | 507 (42) | 21 (41) |
| Extramedullary disease at diagnosis | 23 (2) | 19 (2) | 4 (8) |
AHD, antecedent of hematologic disorder; BM, bone marrow; HiDAC, high-dose cytarabine; Hgb, hemoglobin; LDH, lactate dehydrogenase; PB, peripheral blood; WBC, white blood cell.