Table 3.

Overlap of TAGC asthma-associated SNPs with GWAS catalog association signals by disease group

Disease Group	Number of GWAS catalog association signals	Number of SNPs associated with asthma at Prandom≤10−4 in the multi- ancestry meta-analysis	P-value for overlap
Cardiovascular	743	20	7.8 × 10−42
Body size and morphology	346	2	5.0 × 10−4
Immune/Autoimmune	480	49	3.0 × 10−129
Nervous system	242	4	1.4 × 10−8
Blood	594	10	1.3 × 10−19
Neuropsychiatric	114	5	1.5 × 10−12
Cancer	417	7	4.0 × 10−14
Endocrine system	276	2	4.0 × 10−4
Digestive system	347	16	1.4 × 10−37
Eyes	177	2	2.0 × 10−4
Respiratory system	85	2	3.6 × 10−5
Infectious disease/Infection	104	2	5.3 × 10−5
Urinary system	144	1	1.5 × 10−2
Alcohol, smoking, and illicit substances	30	0	1
Musculoskeletal system	132	0	1

Overlap of TAGC asthma-associated SNPs with association signals of all diseases/traits in the GWAS catalog³ was investigated for all TAGC SNPs having P_random≤10⁻⁴ in the multi-ancestry meta-analysis; diseases from the GWAS catalog were grouped according to the disease classification proposed by Wang et al.³⁷ (note that the “Digestive system” group includes Crohn's Disease, a subtype of Inflammatory Bowel Disease). The significance of overlap was estimated by the binomial tail probability for observing the shown number of TAGC asthma SNPs among the number of SNPs reported in the GWAS catalog for a group of diseases (for example, the probability of observing 20 or more asthma SNPs with P_random≤10⁻⁴ among the 743 cardiovascular SNPs is shown in the last column); a conservative Bonferroni adjusted significance threshold for enrichment in shared associations is 0.05/15=0.003 (for the 15 disease groups investigated).