(b).

Cardiovascular event endpoints	SAVOR TIMI		EXAMINE		TECOS		ELIXA		EMPA-REG		LEADER		SUSTAIN-6		EXSCEL		CANVAS
	Class	HR	Class	HR	Class	HR	Class	HR	Class	HR	Class	HR	Class	HR	Class	HR	Class
Primary composite endpoint MACE	CV death, AMI, or stroke	1 (p = 0.99)	CV death, AMI, or stroke	0.96 (p = 0.315)	CV death, AMI, unstable angina, or stroke	0.98 (p = 0.65)	CV death, AMI, unstable angina, or stroke	1.02 (p = 0.81)	CV death, AMI, or stroke	0.86 (p = 0.04)	CV death, AMI, or stroke	0.87 (p = 0.01)	CV death, AMI, or stroke	0.74 (p < 0.001)	CV death, AMI, or stroke	0.91 (p = 0.39)	CV death, AMI, or stroke
CV death	Primary endpoint	1.03 (p = 0.72)	Primary endpoint	0.85 (p = 0.212)	Primary endpoint	1.03 (p = 0.71)	Primary endpoint	0.98 (p = 0.85)	Primary endpoint	0.62 (p < 0.001)	Primary endpoint	0.78 (p = 0.007)	Primary endpoint	0.98 (p = 0.92)	Secondary endpoint	0.88 (ns)	Secondary endpoint
AMI	Primary endpoint	0.95 (p = 0.52)	Primary endpoint	1.08 (p = 0.47)	Primary endpoint	0.95 (p = 0.49)	Primary endpoint	1.03 (p = 0.71)	Primary endpoint	0.87 (p = 0.23)	Primary endpoint	0.86 (p = 0.046)	Primary endpoint	0.74 (p = 0.12)	Secondary endpoint	2.1 (ns)	Secondary endpoint
Stroke	Primary endpoint	1.11 (p = 0.38)	Primary endpoint	0.91 (p = 0.71)	Primary endpoint	0.97 (p = 0.76)	Primary endpoint	1.12 (p = 0.54)	Primary endpoint	1.18 (p = 0.26)	Primary endpoint	0.86 (p = 0.16)	Primary endpoint	0.61 (p = 0.04)	Secondary endpoint	0.9 (ns)	Secondary endpoint
Hospitalisation unstable angina	Secondary endpoint	1.19 (p = 0.24)	Secondary endpoint	0.90 (p = 0.632)	Primary endpoint	0.90 (p = 0.42)	Primary endpoint	1.11 (p = 0.81)	Secondary endpoint	0.99 (p = 0.97)	Expanded primary endpoint	0.98 (p = 0.87)	Expanded primary endpoint	0.82 (p = 0.49)	Secondary endpoint	2.5 (ns)
Hospitalization heart failure	Secondary endpoint	1.27 (p = 0.007)	Expanded primary endpoint	1.19 (p = 0.220)	Secondary endpoint	1 (p = 0.98)	Secondary endpoint	0.96 (p = 0.75)	Secondary endpoint	0.65 (p = 0.002)	Expanded primary endpoint	0.87 (p = 0.14)	Expanded primary endpoint	1.11 (p = 0.57)	Secondary endpoint	1 (ns)	Secondary endpoint

AMI: acute myocardial infarction; CV: cardiovascular; CVD: cardiovascular disease; HF: heart failure; HR: hazard ratio; MACE: major adverse cardiovascular events.