Figure 1.

Mechanical allodynia and thremal hyperalgesia behavior reduced in Pirt^−/− mouse in CCI models. (a) Hot plate testing over 14 days on WT and Pirt^−/− mice after CCI or sham operation (control), respectively. Values represent the changes from the baseline TWL values that were recorded on day 0 after operation. (b) The TWL values on the 7th day after the operation were compared. (c) Von-Frey testing over 14 days after CCI or sham operation. Values represent the change from the baseline MWT values that were recorded on day 0 after operation. (d) The MWT values on the 7th day after the operation were compared. ^∗P < 0.05, ^∗∗P < 0.01, and ^∗∗∗P < 0.001.