Table 3.
Odds ratios and 95% confidence intervals of mild renal insufficiency (eGFR ≥ 60 and <90 mL/min/1.73 m2) with respect to the presence of NAFLD, MetS, and high hsCRP.
| Model 1a | Model 2b | Model 3c | |
|---|---|---|---|
| NAFLD (−) (ref.) | 1 | 1 | 1 |
| NAFLD (+) | 1.68 (1.28–2.22) | 1.58 (1.17–2.14) | 1.44 (1.03–2.01) |
| P value | <0.001 | 0.003 | 0.034 |
| MetS (−) (ref.) | 1 | 1 | 1 |
| MetS (+) | 2.22 (1.65–2.98) | 1.79 (1.30–2.46) | 1.54 (1.08–2.20) |
| P value | <0.001 | <0.001 | 0.018 |
| hsCRP < 1 mg/L (ref.) | 1 | 1 | 1 |
| hsCRP ≥ 1 mg/L | 1.14 (0.86–1.51) | 1.09 (0.80–1.49) | 0.98 (0.71–1.34) |
| P value | 0.375 | 0.571 | 0.885 |
| NAFLD (−), MetS (−) (ref.) | 1 | 1 | 1 |
| NAFLD (+), MetS (−) | 1.76 (1.23–2.51) | 1.60 (1.09–2.34) | 1.56 (1.05–2.34) |
| NAFLD (−), MetS (+) | 2.93 (1.90–4.52) | 2.03 (1.26–3.25) | 1.82 (1.11–3.00) |
| NAFLD (+), MetS (+) | 2.39 (1.64–3.47) | 2.08 (1.39–3.11) | 1.88 (1.17–3.01) |
| P value | <0.001 | <0.001 | 0.017 |
| NAFLD (−), hsCRP < 1 mg/L (ref.) | 1 | 1 | 1 |
| NAFLD (+), hsCRP < 1 mg/L | 1.74 (1.23–2.47) | 1.54 (1.05–2.25) | 1.42 (0.95–2.12) |
| NAFLD (−), hsCRP ≥ 1 mg/L | 1.10 (0.75–1.61) | 0.99 (0.65–1.50) | 0.93 (0.61–1.42) |
| NAFLD (+), hsCRP ≥ 1 mg/L | 1.76 (1.18–2.60) | 1.68 (1.10–2.57) | 1.43 (0.89–2.30) |
| P value | 0.003 | 0.024 | 0.182 |
eGFR, estimated glomerular filtration rate; NAFLD, nonalcoholic fatty liver disease; MetS, metabolic syndrome; hsCRP, high-sensitivity C-reactive protein. aModel 1 was unadjusted. bModel 2 was adjusted for age, sex, smoking status, alcohol consumption, and physical activity. cModel 3 was adjusted for age, sex, smoking status, alcohol consumption, physical activity, body mass index, aspartate aminotransferase, alanine aminotransferase, and low-density lipoprotein cholesterol.