Table 1. Enrichment of Transcription Factor Binding Sequences in Promoters of Differentially Expressed Genes in SIRT3 KO Cells, Related to Figure 1.
| Transcription Factor | Binding Motif | Frequency | p Value | Adjusted p Value |
|---|---|---|---|---|
| E2F | THVGCGCGAAAAHKR | 0.7551 | 3.48E-06 | 0.004 |
| Pax-3 | TCGTCACRCYYHM | |||
| ATF3 | NBSTGACGTCANCS | |||
| HTF | VDHHWDNDMCACGTCABYNHWNDN | 0.4488 | 2.61E-05 | 0.027 |
| E4F1 | SHTACGTCAC | |||
| CREB | CGTCAB | |||
| Myc | CACGTGB | |||
| N-Myc | NNNCACGTGNNN | |||
| c-Myc:Max | NNNNNNNCACGTGNNNNNNN / NDASCACGTGSTHN | |||
| USF | NCACGTGN / NNRHCACGTGDYNN | 0.5843 | 3.81E-05 | 0.039 |
| SREBP-1 | NATCACGTGAB | |||
| ARNT (HIF1) | NDDDNCACGTGNNNNN / NVNNNRWCACGTGWYNNNBN | |||
| HTF | VDHHWDNDMCACGTCABYNHWNDN |
Differentially expressed genes identified by RNA-seq were used to identify enrichment of transcription factor binding motifs using the previously described MotifADE method.