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. Author manuscript; available in PMC: 2018 Apr 16.
Published in final edited form as: Cell Rep. 2018 Mar 27;22(13):3562–3573. doi: 10.1016/j.celrep.2018.03.008

Figure 5. Analysis of LRIT1 Knockout by Electroretinography.

Figure 5

(A) Representative electroretinography (ERG) waveform recorded from dark-adapted mice in response to scotopic flash of light.

(B) Representative ERG waveform recorded from dark-adapted mice in response to photopic flash of light.

(C) Light-dependence profile of b-wave amplitudes. 4–6 mice were used for each genotype.

(D) Rod-driven component of the b-wave across light intensities recorded in wild-type mice under dark-adapted conditions and various levels of background light. The first phase of the response at scotopic light intensities in (C) is shown.

(E) Rod-driven component of the b-wave across light intensities recorded in Lrit1 knockout mice under dark-adapted conditions and various levels of background light. Dashed lines represent superimposed fits from WT in (D).

(F) Normalized changes in maximal amplitude of the rod-driven b-wave as a function of background light intensity recorded in both genotypes.

(G) Cone-driven component of the b-wave across light intensities recorded in wild-type mice under dark-adapted conditions and various levels of background light. The second phase of the response at photopic light intensities in (C) is shown.

(H) Cone-driven component of the b-wave across light intensities recorded in Lrit1 knockout mice under dark-adapted conditions and various levels of background light. Dashed lines represent superimposed fits from wild-type mice in (G).

(I) Normalized changes in maximal amplitude of the cone-driven b-wave as a function of background light intensity recorded in both genotypes.