Skip to main content
. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Prostaglandins Other Lipid Mediat. 2017 Sep 22;134:108–113. doi: 10.1016/j.prostaglandins.2017.09.004

Figure 2. CYP enzyme production of EET’s, HETE’s and DHETE’s in NP and RUPP rats treated with HET0016.

Figure 2

(a). HET0016 treatment significantly reduced 20-HETE levels in RUPP rats. (b). The sum of HETE isoforms 5-, 8-, 11-, 12-, 15-, 16-, 18- and 19-HETE were not altered with HET0016 treatment in either NP or RUPP rats (c). Total EET’s expressed as the sum of 5,6-, 8,9-, 11,12- and 14,15-EET’s were not significantly altered within any of the groups with or without HET0016. (d). The sum of 5,6-, 8,9-, 11,12- and 14,15-DHETE’s, were not altered with HET0016. (e). Ratio of 20-HETE to total EET’s levels is not changed with HET0016 in NP. HET0016 treatment in RUPP rats reduces the ratio of 20-HETE/EET’s. *P<0.05.