Figure 3.

E₂ treatment of OVX mice reduces T_CORE during the light phase (A, B) with no significant effect on T_SKIN (C, D), heat loss index (E, F) or activity (G, H). The line graphs (left) show the mean values for each group 3 to 5 days after E₂ treatment. The lines are generated with a moving average of 5 points and the black bars on the X axis denote the dark phase. The bar graphs (right) show data analysis (mean ± SEM) from days 3–5. Light vs dark phase differences were identified (B, D, F, H), except for T_SKIN in the OVX + E₂ group (D). Unlike previous studies in the rat, E₂ did not decrease T_SKIN or HLI in the dark phase. n = 9 – 10 mice/group, + Significantly different OVX vs OVX + E₂, p = 0.02, * Significantly different light vs dark within treatment group, p < 0.01, ** Significantly different light vs dark within treatment group, p < 0.001.