Figure 6.
Effects of s.c. injections of the NK3 receptor agonist senktide (or vehicle) on TCORE (top) and TSKIN (bottom) in OVX (left) and OVX + E2 (right) treated mice. Senktide acutely lowered TCORE (A) and increased TSKIN (C) in OVX mice. In OVX + E2 treated mice, the TCORE reduction after senktide was blunted (B) and the acute rise in TSKIN did not occur (D). Values represent mean ± SEM, 0 = time of injection, A and B, n = 9 – 10 mice/group; C, n = 5 mice; D, n = 7 mice, * Significantly different from vehicle, p < 0.01 (TCORE) or 0.05 (TSKIN).