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. 2018 Feb 6;5(1):4–6. doi: 10.1080/23328940.2017.1413155

Figure 1.

Figure 1.

Possible organization of the central pathways mediating the autonomic response to heat-exposure. Excitatory and inhibitory neurons in the anteroventral median preoptic (avMnPO) receive input from thermo-sensory pathways. Inhibitory MnPO neurons monosynaptically inhibit excitatory neurons in the dorsal hypothalamic area and dorsomedial nucleus of the hypothalamus (DHA/DMH) reducing brown adipose tissue (BAT) thermogenesis. Excitatory avMnPO neurons drive inhibitory neurons, possibly in the lateral preoptic (LPO), DHA/DMH and the medullary raphe that inhibit BAT thermogenesis and the activity of cutaneous vasoconstrictor neurons (CVC). Solid lines indicate confirmed pathways, dashed lines indicate putative connections.