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. 2017 Sep 18;9(1-2):192–201. doi: 10.1080/21541248.2017.1346552

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© 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 1. — Illustrative Rab-related pathways used by viruses. I. Rab proteins involved in entry pathways are pictured on the right side of the diagram. Numerous viruses utilize the endocytic pathway to enter cells, and may deliver their capsids to the cytoplasm through Rab5+ or Rab7+ endosomes. II. Rab proteins play critical roles in the assembly and egress of enveloped viruses from cells. Rab11 and Rab 11 FIPs (adaptor proteins) have been implicated in RSV, CMV, and HIV assembly. Rab9 plays a role in late events for several viruses by an as yet unclear mechanism. III. Viral glycoprotein trafficking follows Rab-directed vesicular trafficking pathways, and may involve both outward movement to the plasma membrane and/or endocytosis to intracellular sites of assembly.