Table 1.
Autophagy-related genes linked to immunity in D. melanogaster and C. elegans.
|
D. melanogaster |
S. cerevisiae/H. sapiens |
Pathogen |
Reference |
| Atg1 | Atg1/ULK1 | Wolbachia, VSV | 19,21 |
| Atg6 | VPS30/BECN1 | VSV | 21 |
| Atg2 | ATG2 | VSV | 21 |
| Atg18 | WIPI2 | VSV | 21 |
| Atg9 | ATG9 | VSV | 21 |
| Atg12 | ATG12 | E. coli, VSV | 16,21 |
| Atg7 | ATG7 | E. coli, VSV | 16,21 |
| Atg4 | ATG4 | VSV | 21 |
| Atg5 | ATG5 | L. monocytogenes, E.coli | 14,16 |
| Atg8 | MAP1LC3 | VSV | 21 |
| Park | PRKN | M.marinum, | 18 |
| |
|
S. enterica |
|
|
C. elegans |
S. cerevisiae/H. sapiens |
Pathogen |
Reference |
| unc-51 | Atg1/ULK1 | S. aureus | 41 |
| atg-13 | ATG13 | S. aureus | 19,21 |
| bec-1 | Vps30/BECN1 | S. enterica, | 34,44,45 |
| P. aeruginosa, | |||
| Cry5B | |||
| vps-34 | Vps34/PIK3C3 | S. aureus | 41 |
| atg-2 | ATG2 | S. aureus | 19,21 |
| atg-18 | WIPI2 | N. parisii, | 40,44 |
| Cry5B | |||
| lgg-3 | ATG12 | Cry5B | 44 |
| atg-7 | ATG7 | S. enterica | 34 |
| atg-16.2 | ATG16L1 | S. aureus | 19,21 |
| atg-4.1/2 | ATG4 | Cry5B | 44 |
| lgg-1 | MAP1LC3 | S. aureus, | 34,40,41,44,45 |
| S. enterica, | |||
| P. aeruginosa, | |||
| N. parisii, | |||
| Cry5B | |||
| lgg-2 | MAP1LC3 | S. aureus | 41 |
| sqst-1 | SQSTM1 | N. parisii | 40 |
Autophagy-related genes with reported roles in anti-viral, -bacterial, and -fungal immunity in D. melanogaster and C. elegans are shown, together with the yeast/human homologs. VSV, vesicular stomatitis virus; Cry5B, pore-forming toxin from B. thuringiensis. See Fig. 1 for a functional overview of autophagy genes, and the text for details.