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. 2017 Jul 7;9(1-2):22–48. doi: 10.1080/21541248.2017.1336191

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© 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 1. — Sequence alignment of human Rab G-domains. Conserved nucleotide binding motifs are highlighted: PM1-PM3 - phosphate, magnesium binding motifs; G1-G3 - guanine moiety binding motifs. Rab family specific motifs (RabF1–5), Rab subfamily specific motifs (RabSF1–4) as well as C-terminal interacting motif (CIM) are highlighted. C-terminal cysteines (red) within geranylgeranylation motifs (GGM) are found in one of the following combinations: XXXCC, XXCCX, XCCXX, CCXXX, XXCXC and XCXXX. Hydrophobic triad residues (see Fig. 4) are marked in yellow. Secondary structure elements corresponding to the Rab3 structure (3RAB) are shown on the top, as well as Switch-1, Interswitch, Switch-2, complementarity-determining regions (CDR1–5) and the hyper-variable C-terminal domain (HVD). Rab sequences are presented in an order of proximity in the phylogenetic tree of human Rabs.⁴ The G-domains of closely related Rabs (Rab26 and Rab37) share 76% sequence identity while the more diverse family members (Rab1A and Rab20) exhibit as low as 16% G-domain identity. Among the human Rabs the protein lengths vary between 194 (Rab22a) to 740 residues (RasEF45 or Rab45). Residue conservation color code: red -negatively charged, blue - positively charged, polar - magenta, hydrophobic - green, prolines and glycines -brown. The protein sequences Uniprot database accession numbers: RAB23 Q9ULC3; RAB29 O14966; RAB38 P57729; RAB32 Q13637; RAB9A P51151; RAB7A P51149; RAB28 P51157; RAB20 Q9NX57; RAB34 Q9BZG1; RAB36 O95755; RAB22A Q9UL26; RAB5A P20339; RAB17 Q9H0T7; RAB21 Q9UL25; RAB24 Q969Q5; RAB41 Q5JT25; RAB6A P20340; RAB30 Q15771; RAB33A Q14088; RAB43 Q86YS6; RAB19 A4D1S5; RAB25 P57735; RAB11A P62491; RAB42 NP_001180461.1; RAB39A Q14964; RAB2A P61019; RAB14 P61106; RAB4A P20338; RASEF45 Q8IZ41; RAB44 Q7Z6P3; RAB12 Q6IQ22; RAB18 Q9NP72; RAB3A P20336; RAB27A P51159; RAB26 Q9ULW5; RAB37 Q96AX2; RAB10 P61026; RAB13 P51153; RAB8A P61006; RAB35 Q15286; RAB1A P62820; RAB15 P59190; RAB40A Q8WXH6.