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A model of the positive feedback loop mechanism. Crystal structure of minimal Rabaptin5/Rabex5/Rab5 complex (4Q9U, upper part) shows that the extended Rabaptin5 central coiled-coil domain binds to Rabex5s auto-inhibitory helix, whereas Rabex5 helix-bundle-VPS9 GEF unit interacts with the nucleotide free Rab5a. The structure of Rabaptin5-RBD/Rab5-GTP (1TU3, lower part) represents the complex's membrane-binding unit.
