Figure 2.

The distribution of experimentally and computationally identified AT, AP and NE proteins across 164 eukaryotes in THANATOS database. In our results, there were only 1,909, 1,134, 340, 39, 153, 77, 189 and 37 known AT, AP and/or NE proteins experimentally identified in H. sapiens, M. musculus, R. norvegicus, D. rerio, D. melanogaster, C. elegans, S. cerevisiae and A. thaliana respectively, whereas the integrative data set in total contained 12,222 proteins for the 8 species, with a >2-fold increase (Table S2). In total, THANATOS contains 191,543 proteins potentially associated with autophagy cell death pathways.