Table 2.
Univariate and multivariate analyses of clinicopathological characteristics.
| Univariate analysisa |
Multivariate analysisb |
|||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| laterality | 1.454(1.056-2.003) | 0.021 | 1.390 (0.962-2.009) | 0.08 |
| gender | 0.950 (0.684-1.321) | 0.762 | ||
| age | 0.823(0.458–1.478) | 0.514 | ||
| person neoplasm cancer status | 6.080(4.241-8.717) | <0.001 | 3.540(2.322-5.397) | <0.001 |
| lactate dehydrogenase | 1.488 (0.507-4.363) | 0.467 | ||
| serum calcium | 0.756 (0.530-1.079) | 0.122 | ||
| hemoglobin | 2.109(1.450-3.068) | <0.001 | 1.364 (0.886-2.102) | 0.159 |
| platelet qualitative | 2.415(1.690-3.450) | <0.001 | 1.680(1.121-2.518) | 0.012 |
| white cell count | 0.696 (0.486-0.998) | 0.047 | 0.998 (0.667-1.494) | 0.992 |
| stage event system version | 0.698 (0.252-1.932) | 0.486 | ||
| stage event pathologic stage | 4.591(3.242-6.502) | <0.001 | 2.406(1.540-3.757) | <0.001 |
| Neoplasm histologic grade | 2.838(1.950-4.129) | <0.001 | 1.168 (0.757-1.801) | 0.484 |
| T stage | 5.149(2.691-9.852) | <0.001 | 1.975 (0.889-4.388) | 0.095 |
| N stage | 1.559 (0.354-6.876) | 0.555 | ||
| M stage | 0.253 (0.062-1.027) | 0.038 | 0.367 (0.080-1.677) | 0.196 |
| Has-miR-200c | 0.580 (0.344-0.977) | 0.038 | 0.571 (0.325-1.002) | 0.051 |
| SLC6A1 | 1.498(1.084-2.072) | 0.014 | 1.454(1.056-2.003) | 0.021 |
a
The data were subjected to Cox's proportional hazards regression model. Bold italics indicate statistically significant values (P < 0.05).
b
Multivariate analysis used stepwise addition and removal of clinical covariates found to be associated with survival in univariate models (P < 0.05) and final models, include only those covariates that were significantly associated with survival (Wald statistic, P < 0.05). Bold italics indicate statistically significant values (P < 0.05).