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. 2018 Feb 22;19(4):260–270. doi: 10.1080/15384047.2016.1250981

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© 2018 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 3. — miR-326 and curcumin combination treatment promoted apoptosis and restrained the migration of glioma cells. (A) The annexin V-PI assay revealed increased apoptosis in glioma cells following combination treatment. Percentages of apoptotic cells are shown in the histogram. (B) Western blot assay of the levels of caspase-3, cleaved PARP, caspase-8, MCL1, bcl-xl and RIP1 after miR-326 and curcumin treatment alone and in combination. (C) Western blot of the expression of caspase-3 and caspase-8 after transfected either with negative control or 3 different siRNA sequences againest caspase-3 and caspase-8. (D) Cell death of different treatments was determined by trypan blue staining. (E) Cell migration was analyzed using the transwell assay. Bars represent 200 μm. The data represent the mean ± SEM of 3 replicates (*P < 0.05; **P < 0.01, and ***P < 0.001).