Table 3.

Univariate and multivariate analysis of clinicopathologic variables in relation to liver metastasis and overall survival after curative operation.

			Liver Metastasis			Overall Survival
			Univariate analysis	Multivariate analysis		Univariateanalysis	Multivariate analysis
Parameter		N	P value	HR(95% CI)	P value	P value	HR(95% CI)	P value
Gender	Male	98	0.92			0.59
	Female	57
Age(years)	<65	85	0.43			0.11
	≥65	70
Albumin(g/dL)	<3.5	18	0.39			0.89
	≥3.5	137
CEA(ng/mL)	<5	114	0.12			0.00	1	0.04
	≥5	41					1.63(1.04-2.59)
CA125(U/mL)	<35	124	0.91			0.05	1	0.08
	≥35	31					1.619(0.95-2.74)
CA19-9(U/mL)	<39	32	0.11			0.01	1	0.56
	≥39	123					1.15(0.71-1.87)
ABO	A	55	0.13			0.94
	AB	19
	B	48
	O	33
Location	Uncinate process	48	0.80			0.43
	Head	71
	Body and tail	36
Differentiation	Poor	75	0.20			0.16
	Well to moderate	80
Diameter(cm)	<3.5	68	0.20			0.01	1	0.04
	≥3.5	87					1.50 (1.02-2.22)
T staging	1-2	54	0.01	1	0.03	<0.01	1	0.04
	3-4	101		1.67(1.06-2.62)			1.55(1.03-2.33)
LN metastasis	Negative	69	0.15			<0.01	1	<0.01
	Positive	86					1.95(1.32-2.87)
AJCC	<IIb	67	0.08	1	0.33	<0.01	1	0.88
	≥IIb	88		1.234(0.81-1.89)			1.12(0.26-4.74)
Stromal TILs	Positive	100	<0.01	1	<0.01	<0.01	1	<0.01
	Negative	55		2.80(1.75-4.48)			2.70(1.80-4.06)

Abbreviations: TILs = tumor-infiltrating lymphocytes; LN = lymph node; HR = hazard ratio; CI = confidence interval.