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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: J Thromb Haemost. 2017 May 3;15(6):1095–1102. doi: 10.1111/jth.13683

Figure 2.

Figure 2

Anti-angiogenic TKI administration effectively reduces GI bleeding in the Alk1-iKO model. A. Cross sectional view of ceca showing signs of bleeding (dark brown). GI bleeding phenotypes are categorized according to the severity of cecal hemorrhages. No, moderate, and severe blood filled ceca were scored 0, 1, and 2, respectively. Four representative images in each scale were shown regardless of the treatment conditions. B and C. GI bleeding index indicates that sorafenib, sunitinib or GW771806 significantly alleviated but erlotinib exacerbated GI hemorrhages compared with controls. ** P<0.01 and *** P<0.001. Error bars in B and C indicate SD.