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. Author manuscript; available in PMC: 2018 May 22.
Published in final edited form as: Sci Transl Med. 2017 Nov 22;9(417):eaan8462. doi: 10.1126/scitranslmed.aan8462

Fig. 4. MMP-7 biomarker validation and hepatic expression.

Fig. 4

(A) ROC curves in discovery and validation cohort #1 for MMP-7, ENPP7, and GGT. (B) Scatter plot of serum MMP-7 of randomly selected samples from biliary atresia (BA: N=10), intrahepatic cholestasis (IHC; N=10), and normal controls (NC; N=4) measured by antibody-based enzyme-linked immunosorbent assay compared with (C) the values measured by SOMAScan®. Data is presented as median and interquartile range. (D) Hepatic mRNA expression of MMP-7 for BA (N=64), IHC (N=14), and NC (N=7). Expression levels are normalized to normal controls and are presented as fold change. P-values from Kruskal-Wallis test.