Figure 2. Effect of Boxb treatment on TLR4, MyD88, HMGB1, IL-1β and TNF-α in BALB/c mice corneas.

Corneas of BALB/c mice pretreated with Boxb compared with PBS at 1d. The mRNA expressions of TLR4 (A), HMGB1 (B), TNF-α (C), IL-1β (D) were significantly increased. And the protein levels of TLR4 (E), MyD88 (F), TNF-α (G) and IL-1β (H) were also increased. ^a P<0.05, ^bP<0.01 vs PBS+A. fumigatus group.