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. 2018 Apr 18;11(4):548–552. doi: 10.18240/ijo.2018.04.02

Figure 3. Effects of Boxb treatment on TLR4, MyD88, HMGB1, IL-1β and TNF-α in macrophages of BALB/c mice.

Figure 3

Macrophages treated with Boxb compared with normal, PBS, CLI-095+Boxb, and DMSO+Boxb at 12h. A: The level of TLR4 mRNA was elevated in Boxb+A. fumigatus group, and in the CLI-095+Boxb+A. fumigatus group the TLR4 mRNA was declined; B: The mRNA level of HMGB1 was elevated in Boxb+A. fumigatus group, and the CLI-095 inhibited the HMGB1 mRNA expression; C: The level of TNF-α mRNA was significantly higher in Boxb+A. fumigatus group, and the CLI-095+Boxb+A. fumigatus group the expression was declined; D: The mRNA level of IL-1β was elevated in Boxb+A. fumigatus group, and declined in the CLI-095+Boxb+A. fumigatus group; E: The protein level of TLR4 was elevated in Boxb+A. fumigatus group, and declined in the CLI-095+Boxb+A. fumigatus group; F: The protein level of MyD88 was increased in Boxb+A. fumigatus group, and the CLI-095+Boxb+A. fumigatus group was significantly decreased. a P<0.05; bP<0.001; cP<0.01 vs PBS+A. fumigatus group; dP<0.001 vs Boxb+A. fumigatus group; eP<0.001; fP<0.01; gP<0.05 vs CLI-095+Boxb+A. fumigatus group.