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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: J Autoimmun. 2018 Jan 4;89:171–185. doi: 10.1016/j.jaut.2017.12.017

Figure 6. The 16-residue alignment among different desmosomal proteins.

Figure 6

The 16-residue peptide bound by 19/20 FS IgG4 (A129 to R144) on Dsg1 was aligned with similar peptides from Dsg2, Dsg3, Dsg4, Dsc1 and E-Cadherin. The Dsg4 peptide shows two residues, R133 and E135 that are different from the Dsg1 counterpart. Human Dsg4 does not bind FS IgG or IgG4 autoantibodies.