Figure 5.

Prelimbic (PL) activation prevents stress-induced reduction in social exploration. (A) Schematic representation of cannula placements within the PL. Numerals indicate in mm distance from bregma. For clarity, only cannulae from picrotoxin-treated groups are shown. (B) Escapable shock (ES), inescapable shock (IS), and home cage control (HC) subjects received intra-PL picrotoxin (PTX) or vehicle (VEH) 30 min prior to stress exposure. A 3 min juvenile social exploration test was given 24 h later. Bars represent mean (± SEM) social exploration expressed as the percentage of baseline exploration, **p < 0.01 compared to HC of the same drug treatment.