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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Wiley Interdiscip Rev Syst Biol Med. 2018 Jan 15;10(3):e1415. doi: 10.1002/wsbm.1415

FIGURE 5.

FIGURE 5

PPi detection systems based on split FPs that use exogenous chromophores. (a) iSplit50 is a split version of the iRFP protein.49 Reconstitution of iRFP due to the interaction of X and Y activates the fluorescence of the bound biliverdin molecule. (b) IFP PCA79 is a split version of IFP1.4 that is reported to be reversible.78 (c) uPPI81 is based on split UnaG and depends on the X and Y PPi to activate fluorescence of a bound bilirubin molecule.