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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Wiley Interdiscip Rev Syst Biol Med. 2018 Jan 15;10(3):e1415. doi: 10.1002/wsbm.1415

TABLE 2.

Split luciferases.

Organism Species Luciferase name Length (amino acids) Size kDa Split name N-terminal split Split name C-terminal split Substrate
Firefly Photinus pyralis Firefly Luciferase 550 61 NLuc 2–416 CLuc 398–550 D-luciferin
Click beetle Pyrophorus plagiophthalamus Click Beetle Red 542 64 CBR (1–414) 1–414 CBR (395–542) 395–542 D-luciferin
Click beetle Pyrearinus termitilluminans Emerald Luciferase 542 64 ELucN 1–415 ELucC 394–542 D-luciferin
Sea pansy Renilla reniformis Renilla Luciferase 311 36 N-Rluc 1–229 C-Rluc 230–311 Coelenterazine
Copepod Gaussia princeps Gaussia Luciferase 185 20 Gluc(1) 1–93 Gluc(2) 94–185 Coelenterazine
Shrimp Oplophorus gracilirostris Nanoluc 171 19 N65 1–65 66C 66–171 Furimazine
NanoBiT 171 19 11S 1–156 114 158–168 Furimazine