Table 3.
Adjusted probabilities of outcomes after HCT
|
|
|||||
|---|---|---|---|---|---|
| N at risk | TBI Prob (95% CI) |
N at risk | BU Prob (95% CI) |
p-value* | |
| aGVHD, grades II-IV | |||||
| day 100 | 431 | 40 (37-43)% | 140 | 47 (42-53)% | 0.025 |
| cGVHD | |||||
| 1 yr | 212 | 47 (43-50)% | 79 | 41 (36-47)% | 0.10 |
| 3 yr | 87 | 55 (52-59)% | 25 | 49 (43-55)% | 0.073 |
| TRM | |||||
| 1 yr | 470 | 16 (14-19)% | 149 | 16 (12-20)% | 0.89 |
| 3 yr | 282 | 25 (22-28)% | 76 | 19 (14-23)% | 0.039 |
| 5 yr | 198 | 27 (24-31)% | 32 | 22 (17-27)% | 0.11 |
| Relapse | |||||
| 1 yr | 470 | 19 (17-22)% | 149 | 25 (20-30)% | 0.064 |
| 3 yr | 282 | 28 (25-31)% | 76 | 37 (31-43)% | 0.0074 |
| 5 yr | 198 | 29 (26-32)% | 32 | 42 (35-48)% | 0.00050 |
| DFS | |||||
| 1 yr | 470 | 65 (61-68)% | 149 | 60 (54-65)% | 0.14 |
| 3 yr | 282 | 48 (45-52)% | 76 | 45 (39-51)% | 0.35 |
| 5 yr | 198 | 45 (41-49)% | 32 | 37 (30-43)% | 0.035 |
| OS | |||||
| 1 yr | 541 | 74 (71-77)% | 177 | 69 (64-74)% | 0.11 |
| 3 yr | 316 | 53 (50-57)% | 98 | 57 (50-62)% | 0.35 |
| 5 yr | 222 | 49 (45-52)% | 39 | 46 (39-53)% | 0.51 |
*
Adjusted point-wise estimates
Abbreviations: TBI, total body irradiation; BU, busulfan; GVHD, graft-versus-host disease; TRM, treatment related mortality; DFS, disease-free survival; OS, overall survival; N, number; Prob, probability; CI, confidence interval; HCT, hematopoietic cell transplantation