Table 2.
Unadjusted associations of age, sex, education and comorbid conditions on the prevalence of neurocognitive impairment a
| Variable | n (%) impaired | Prevalence ratio (95% CI) | P |
|---|---|---|---|
| Age, years | |||
| Under 35 | 18/71 (25.4) | 1 | |
| 35–50 | 91/246 (37.0) | 1.46 (0.95–2.25) | |
| 51–59 | 35/104 (33.7) | 1.33 (0.82–2.15) | |
| 60+ | 12/27 (44.4) | 1.75 (0.98–3.14) | |
| Per +10 years | 1.13 (1.00–1.29) | 0.056 | |
| Sexual orientation and gender | |||
| MSM | 91/317 (28.7) | 1 | |
| Heterosexual men | 36/61 (59.0) | 2.03 (1.53–2.69) | <0.001 |
| Women (all) | 29/70 (41.4) | 1.44 (1.04–2.00) | 0.029 |
| University educated | |||
| No | 91/199 (45.7) | 1 | |
| Yes | 65/249 (26.1) | 0.57 (0.44–0.74) | <0.001 |
| Confounding conditionb | |||
| No | 117/367 (31.9) | 1 | |
| Yes | 39/81 (48.2) | 1.51 (1.15–1.98) | 0.003 |
| Contributing conditionb | |||
| No | 131/385 (34.0) | 1 | |
| Yes | 25/63 (39.7) | 1.17 (0.83–1.63) | 0.37 |
CI confidence interval
aNeurocognitive impairment was defined as s z ≤ −1 in at least 2 out of 5 cognitive domains
bConfounding and contributing conditions as defined in published criteria for HIV-associated neurocognitive disorders (12)